Chronic granulomatous disease: A report of 5 cases

Abstract

In the last 2 years chronic granulomatous disease (CGD) was diagnosed in 5 children in the children's medical center in Tehran. All of them had been referred because of severe recurrent infections. 4 patients were male, their parents being first cousins. Laboratory tests were normal for chemotaxis, serum complements and T-cells. NBT tests were severely abnormal. 2 patients were tested for cell antigen, the results being negative in both of them. 4 patients, in whom serum immunoglobulins were studied, 2 showed high immunoglobulin levels, one had normal values and one was immune deficient. The treatment consisted in intravenous antibiotics for a long period and surgical intervention where needed. The immunodeficient patient improved by ?-globulin injection.