Precocious puberty and primary hypothyroidism

Abstract

We report a 7-year-old Iranian girl with precocious puberty due to primary hypothyroidism. She is a case of thyroid gland dysgenesis that leads to thyroprivic hypothyroidism with concomitant hyperprolactinemia, elevated gonadotropin level, enlarged uterus, polycystic ovarious and hyperesterogenism with natural breasts and menarche. With thyroid replacement therapy her breasts regressed, ovarian cysts disappeared and serum gonadotropin, prolactin and estrogen levels returned to normal values. We conclude that hypothyroidism is a rare cause of true precocious puberty and the impaired feedback control of hypothalamic pituitary pathway in these patients will be suppressed with thyroxin