Gastrointestinal complications of non-Steroidal anti-inflammatory drugs

Abstract

Non-steroid anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs in rheumatic disorders. This group of drugs has been associated with various degrees of gastroduodenopathy (GD), which is due to inhibition of prostaglandin (PG) synthesis. There are several differences between their side effect in stomach and in duodenum. But all these drugs have gastrointestinal side effect. Several studies on preventing NSAIDs GD have been performed in Europe and north America. There are several differences in safety profiles between various NSAIDs and NSAIDs GD prevention effect of cimetidine, ranitidine and omeprazol. The incidence of NSAIDs GD was different depending on NSAIDs, and the patient’s genetic bone. The incidence of NSAIDs-induced gastric ulcers was higher, compared to Europe and north America, and that of duodenal ulcers was lower. The reason is the difference in basic acid output. In this study the incidence of NSAIDs GD compared to that of western patients was the same (Gastric ulcer 18% and duodenal ulcer 14%). The NSAIDs GD preventive effects of omeprazol and H2 blocker (Cimetidine, ranitidine), were significant when compared to placebo.