Iranian Journal of Pediatrics 2002. 12(4):37-41.

A comparative study between Sabril (Vigabatrin) and ACTH in treatment of infantile spasms
Amir Salari S, Ghofrani M

Abstract


Infantile spasms (IS) is an age specific epileptic syndrome. With respect to poor response of IS to conventional anti-epileptic drugs, scientists tend to find new effective drugs. In this study, 50 infants with IS in the age group of 2-24 months, were divided randomly into 2 equal groups, treated with sabril or ACTH and compared for clinical efficacy and drug side effects. After 6 week of treatment is sabril group there was 28% complete remission and 40% reduction in seizure frequencies while in ACTH group there was 40.9% complete remission and 45.5% reduction in seizure frequencies, showing no significant difference between clinical responses in the two groups. Drug side effects were seen in 16% of patients in sabril group and 81.8% of those in ACTH group. These differences were significant from statistical point of view. Unfortunately, it is impossible to evaluate visual field constriction, a probable irreversible side effect of sabril. This justified the use ACTH as the first line of treatment in IS.

Keywords


infantile spasms, Hypsarhythmia, ACTH, Sabril,

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