Convulsions caused by Pseudohypoparathyroidism

Abstract

A 12-year-old girl was suffering of convulsions since 2 years of age and was being treated with anti-epileptic drugs without any effect. Evaluation of the disease revealed Pseudohypoparathyroidism as the cause of convulsions. Pseudohypoparathyroidism is a rare, hereditary disease, inherited as an X-linked dominant trait. The clinical and radiologic signs are conspicuous. Thyroid hormone secretion is normal. Calcium levels in blood serum are decreased and phosphorus increased. Parathormone has no effect on serum calcium levels or urinary CAMP secretion. Associated hormone disturbances in some reports suggest Pseudohypoparathyroidism as a generalized endocrinopathy. Vitamin D or calcitriol administration normalizes serum calcium levels and the convulsions subside thereof