Prevalence of growth hormone deficiency in children with short stature
Abstract
Background: The prevalence of growth hormone deficiency (GHD) has been reported differently in previous studies.
Methods: This case-series study includes 120 children with short stature aged between 4-15 years referred to Endocrine and Metabolism Center (1997-98) in Tehran.
These children have been observed at least 6-12 months. Initial evaluation includes: complete blood count (CBC), erythrocyte sedimentation rate (ESR), calcium, phosphor, Alkaline Phosphates, urea, cratinine, triiodothyronine (T3), Thyroxin T4, thyrotropin-stimulating hormone (TSH), urinalysis, urine culture, stool exam, karyotyping (in girls) and bone age investigation. GH was measured by two standard stimulation tests. Peak levels of GH less than 10µg/lit in two provocative tests are compatible with GH deficiency.
Results: Twenty children (17.4%) had GHD. Fourteen of them were boys. Bone age in 15 (60%) cases was delayed and the height was more than 3 SD below the mean for age. Two children had deficiency of other hypophysial hormones and one of them suffered from craniopharyngioma.
Conclusion: In this study prevalence of GHD was more than in pervious investigation, because it has been performed in a referral center of endocrine diseases.
Methods: This case-series study includes 120 children with short stature aged between 4-15 years referred to Endocrine and Metabolism Center (1997-98) in Tehran.
These children have been observed at least 6-12 months. Initial evaluation includes: complete blood count (CBC), erythrocyte sedimentation rate (ESR), calcium, phosphor, Alkaline Phosphates, urea, cratinine, triiodothyronine (T3), Thyroxin T4, thyrotropin-stimulating hormone (TSH), urinalysis, urine culture, stool exam, karyotyping (in girls) and bone age investigation. GH was measured by two standard stimulation tests. Peak levels of GH less than 10µg/lit in two provocative tests are compatible with GH deficiency.
Results: Twenty children (17.4%) had GHD. Fourteen of them were boys. Bone age in 15 (60%) cases was delayed and the height was more than 3 SD below the mean for age. Two children had deficiency of other hypophysial hormones and one of them suffered from craniopharyngioma.
Conclusion: In this study prevalence of GHD was more than in pervious investigation, because it has been performed in a referral center of endocrine diseases.
Keywords
Growth hormone deficiency, GH, Short stature, bone age, Growth retardation,
Full Text:
PDFRefbacks
- There are currently no refbacks.